Fig. 2

Overexpression of miR-9-5p reversed the activation of inflammatory pathway in TNF-α- and IL-6beta-treated BMSCs. a Expression of miR-9-5p was suppressed by IL-6 and TNF-α treatment which was reversed by miR-9-5p mimic transfection. b IL-6 and TNF-α treatment enhanced REST mRNA level which was reversed by miR-9-5p mimic transfection. c–e IL-6 and TNF-α treatment enhanced TNF-α (c), IL-6 (d), and IL-1beta mRNA which was reversed by miR-9-5p mimic transfection. f IL-6 and TNF-α treatment decreases cell viability which was reversed by miR-9-5p mimic transfection. g IL-6 and TNF-α treatment enhanced caspase 3 mRNA level which was reversed by miR-9-5p mimic transfection. qRT-PCR was used to evaluate mRNA level. Mean ± SD is used to present all data. *p < 0.05, **p < 0.01, and ***p < 0.001