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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: The analgesic action of larixyl acetate, a potent TRPC6 inhibitor, in rat neuropathic pain model induced by spared nerve injury

Fig. 10

The effects of TRPC6 knockdown and the co-administration with LA on pp38 immunofluorescent staining in SNI rats. ad Mismatch group, eh antisense group, i, j mismatch supplemented with LA at 30 μM, mp antisense supplemented with LA at 30 μM. pp38 IR (in green) in the mismatch group were markedly increased in the medial two thirds part of the ipsilateral SDH, compared to the sporadic distribution in the contralateral side (data not shown). Most of pp38 IR were co-existed with Iba-1, suggesting the dominant localization in the microglia (d). Antisense or the two co-administrations caused prominent decrease of pp38 IR and Iba-1 IR (in red). d, h, l, p Illustrated the magnified images enclosed in c, g, k, o, respectively. Nerve injury caused the upregulation of pp38 IR in the soma and processes of microglia (d). But those in the processes were markedly reduced in the antisense and co-administration groups (h, l, p). Scale bar, 30 μm in d, h, l, p; 100 μm in the remaining pictures

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