Fig. 7
DMI alleviates the severity of relapse in relapsing-remitting EAE. SJL/J mice (n = 12/group) were immunized with PLP139–151 to induce EAE. Following the first remission and before the onset of relapse, EAE mice were administered i.p. with vehicle or DMI (400 mg/kg) every day. The clinical score of EAE mice was evaluated for a period of 20 days. The incidence and mortality rate of vehicle- and DMI-treated EAE mice were accessed, and the mean ± SEM of onset of disease, maximum score, average score, and cumulative score of day 1 to day 20 post-treatment in vehicle- and DMI-treated EAE was calculated. Statistical significance was determined as *p < 0.05, **p < 0.01, and ***p < 0.001 by Mann-Whitney U test