Fig. 4

Cardiovascular and cerebrovascular changes. Mean arterial pressure (MAP), carotid artery blood flow (CaBF), fetal heart rate (FHR), carotid artery vascular conductance (CaVC), EEG power, femoral artery blood flow (FBF), nuchal electromyography (EMG), and femoral artery vascular conductance (FVC) in the control (open circles, n = 7), LPS (red circles, n = 8) and ET + LPS (blue circles, n = 8) groups. The light shaded area represents the period of low dose LPS infusion, and the dark shaded area represents the period of increased infusion. The dashed vertical lines show the timing of LPS/saline bolus administration. Data are hourly means ± SEM. LPS, lipopolysaccharide, ET, Etanercept; a = P < 0.05 LPS vs. control, b = P < 0.05 ET + LPS vs. control, c = P < 0.05 LPS vs. ET + LPS