Fig. 5

Exercise increases the number of microglia process in the CA1 region of hippocampus following cerebral hypoperfusion. Representative confocal images of microglia morphology (Iba1⁺, yellow) in vessels of the hippocampus (IB4, red) of animals that were exercised or sedentary for 12 weeks after cerebral hypoperfusion (2VO-Ex and 2VO-Sed, respectively) or after sham surgery (Sham-Ex and Sham-Sed, respectively). Data represent the mean ± SEM of up to 40 microglial cells per group of 3 animals. In a number of microglia in the hippocampus, b and c number of microglia branches. *p < 0.05 vs. Sham-Sed and **p < 0.01 vs. Sham-Sed; ^#p < 0.05 and ^##p < 0.01 vs. 2VO-Sed (ANOVA). Scale bar 50 μm, magnification 200X