Fig. 2
From: Transcriptomic profiling of microglia and astrocytes throughout aging
Differential gene expression between adult and aging microglia. a–d Upregulated and downregulated genes, determined using DESeq2 analysis, between mature-adult mice (2 months) and aging mice (4 months, 6 months, 9 months, 12 months); adjusted p < 0.05, |log2 fold-change| > 0.5. a Venn diagram showing upregulated genes in microglia. b Heatmap of top 15 genes upregulated in microglia. c Venn diagram showing downregulated genes in microglia. d Heatmap of top 15 genes downregulated in microglia. e and f STEM analysis of upregulated genes (e) and downregulated genes (f) in microglia during aging