Fig. 4
From: Transcriptomic profiling of microglia and astrocytes throughout aging
Differential gene expression between adult and aging astrocytes. a–d Upregulated and downregulated genes, determined using DESeq2 analysis, between mature-adult mice (2 months) and aging mice (4 months, 6 months, 9 months, 12 monts); adjusted p < 0.05, |log2 fold-change| > 0.5. a Venn diagram showing upregulated genes in astrocytes. b Heatmap of top 15 genes upregulated in astrocytes. c Venn diagram showing downregulated genes in astrocytes. d Heatmap of top 15 genes downregulated in astrocytes. e and f STEM analysis of upregulated genes (e) and downregulated genes (f) in astrocytes during aging