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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Deterioration of cognitive function after transient cerebral ischemia with amyloid-β infusion—possible amelioration of cognitive function by AT2 receptor activation

Fig. 2

Effect of BCCAO with/without Aβ1-40 on cognitive function evaluated by MWMT. Three weeks after injection, MWMT was performed. Time courses of escape latency from day 1 to day 5 in MWMT in WT and smAT2 (a) mice are shown. b Comparison of escape latency on day 5 between WT and smAT2 mice. Comparison of CBF is shown in c. After the MWMT, CBF was determined by laser speckle flowmetry. Quantification of the volume of mean CBF analyzed by computer software is shown. *P < 0.05, P < 0.01 vs. PBS, BCCAO (−) in WT on days 2, 3, 4, and 5, respectively. #P < 0.05 vs. PBS, BCCAO (+) and Aβ, BCCAO (−) in WT on day 5, respectively. n = 12 in WT-PBS, BCCAO (−); n = 12 in WT-PBS, BCCAO (+); n = 15 in WT-Aβ, BCCAO (−); n = 14 in WT-Aβ, BCCAO (+); n = 8 in smAT2-PBS, BCCAO (−); n = 9 in smAT2-PBS, BCCAO (+); n = 14 in smAT2-Aβ, BCCAO (−); n = 14 in smAT2-Aβ, BCCAO (+)

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