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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson’s disease brain

Fig. 2

Human microglia do not express markers required for activation of CD4+ T cells, following αSYN-F treatment. Schematic illustration of study setup and the different treatment groups (a). Human microglia accumulate αSYN that partially co-localize with the lysosomal marker CD68 (b). Flow cytometry analysis revealed that microglia cells upregulate MHC-II (c) and MHC-I (d) upon IFNγ treatment,which are involved in activation of T cells. However, when exposed to αSYN-F, the microglia did not express co-stimulatory markers CD40 (e), CD80 (f), and CD86 (g) that are all necessary for activating CD4+ T cells. U, unstained samples; GFI, geometric fluorescence intensity

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