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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson’s disease brain

Fig. 3

Human astrocytes express all markers required for activation of CD4+ T cells following αSYN-F treatment. Schematic illustration of study setup and the different treatment groups (a). Flow cytometry analysis illustrated that astrocytes upregulate MHC-II (b), MHC-I (c), and PDL1 (d) upon IFNγ treatment ,which are involved in activation (MHC-II and MHC-I) and inhibition (PDL1) of T cells. Notably, when exposed to αSYN-F, the astrocytes express all co-stimulatory markers CD40 (e), CD80 (f), and CD86 (g) that are crucial for activating CD4+ T cells. U, unstained samples; MFI, mean fluorescence intensity

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