Fig. 5
From: Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits
Restriction of neurotoxic iron accumulation ameliorates GA-induced cognitive deficits in the adolescent rats and aged mice. a Escape latency during the spatial training of MWM for 5 consecutive days. Rat pups received different treatments including GA or/and DFP exposure daily for three consecutive days from PND 6 to PND 8. The MWM tests were performed at PND 60. b Representative swimming trajectory of the rats. c Time spent in the target quadrant, d crossing platform times, and e swim speed in the probe trial of MWM. f Freezing time to context and g freezing time to tone in the fear conditioning tests. The fear conditioning tests for the aged mice were performed 24 h after GA exposure. a–e for adolescent rats; f and g for aged mice. Data are presented as mean ± SEM (n = 12 animals/group); *p < 0.05 compared with Con group; #p < 0.05 compared with the GA (Ket or Sev) group