Table 1 Specific and non-specific NLRP3 inhibitors investigated in the context of TBI
From: The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target
Inhibitor | NLRP3 specific? | Pre-clinical TBI studies | Species | Model of TBI |
|---|---|---|---|---|
MCC950 | Yes (NLRP3 NACHT domain) | Mouse | CCI | |
JC124 | Yes (unknown) | [92] | Rat | CCI |
Bay 11-7082 | No | Rat and mouse | CCI, weight-drop, and fluid percussion | |
Mangiferin | No | [83] | Rat | Blast |
Omega-3 fatty acids | No | [71] | Rat | CCI |
Apocynin | No | [84] | Mouse | CCI |
Propofol | No | [85] | Rat | Blast |
Telmisartan | No | [86] | Mouse | Cryogenic |