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Table 2 Summary of the findings

From: The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function

A. Expression of HCN and KCNQ subunits in activated microglia compared to untreated microglia
Pro-inflammatory microgliaAnti-inflammatory microglia
• HCN2 ↓HCN3 ↓
• KCNQ 3 ↑KCNQ 5 ↑
• HCN2 ↑HCN3 ↓
• KCNQ 3 ↓KCNQ 5 ↓
B. Effects of HCN and Kv7/KCNQ channel blockade on microglia
HCN-blockadeKv7/KCNQ-blockade
• survival ↑
• proliferation ↓
• activation ↓
• phagocytotic capacity ↑
• no effects on migration
• migration ↓
• no effects on survival, proliferation, phagocytotic capacity and activation