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Table 2 Summary of the findings

From: The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function

A. Expression of HCN and KCNQ subunits in activated microglia compared to untreated microglia

Pro-inflammatory microglia

Anti-inflammatory microglia

• HCN2 ↓HCN3 ↓

• KCNQ 3 ↑KCNQ 5 ↑

• HCN2 ↑HCN3 ↓

• KCNQ 3 ↓KCNQ 5 ↓

B. Effects of HCN and Kv7/KCNQ channel blockade on microglia

HCN-blockade

Kv7/KCNQ-blockade

• survival ↑

• proliferation ↓

• activation ↓

• phagocytotic capacity ↑

• no effects on migration

• migration ↓

• no effects on survival, proliferation, phagocytotic capacity and activation