A. Expression of HCN and KCNQ subunits in activated microglia compared to untreated microglia | |
---|---|
Pro-inflammatory microglia | Anti-inflammatory microglia |
• HCN2 ↓HCN3 ↓ • KCNQ 3 ↑KCNQ 5 ↑ | • HCN2 ↑HCN3 ↓ • KCNQ 3 ↓KCNQ 5 ↓ |
B. Effects of HCN and Kv7/KCNQ channel blockade on microglia | |
HCN-blockade | Kv7/KCNQ-blockade |
• survival ↑ • proliferation ↓ • activation ↓ • phagocytotic capacity ↑ • no effects on migration | • migration ↓ • no effects on survival, proliferation, phagocytotic capacity and activation |