Skip to main content
Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke

Fig. 3

The mRNA expression of three cell adhesion molecules and KLF4 in the ischemic brain following focal cerebral ischemia. The mRNA levels of E-selectin, VCAM-1, ICAM-1, and KLF4 in the ipsilateral ischemic cerebral cortex from sham-operated mice (S, control) or mice at days 1, 2, 4, 7, and 14 post-ischemia was measured by qPCR. Results are expressed as the mean ± standard deviation (n = 4 per experimental group). Note that cerebral ischemia markedly increased the mRNA expression of all the three cell adhesion molecules including E-selectin, VCAM-1, and ICAM-1 in the ischemic hemisphere, reaching a peak at day 1 or 2 and then declining at day 2 or 4, while cerebral ischemia also induced a strong increase in mRNA expression of KLF4 over the entire 14-day time course, with this effect maximal between 7 and 14 days post-ischemia. *P < 0.05, **P < 0.01, ***P < 0.001 compared with control

Back to article page