KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke

Table 2 The comparison of serum levels of three cell adhesion molecules, KLF4, and infarct volume at 48 h after ischemic onset in patients with minor and moderate to severe stroke and healthy controls

Variable	Controls (n = 33)	NIHSS < 7 (n = 39)	NIHSS ≥ 7 (n = 35)
E-selectin, ng/ml, mean ± SD	1.32 ± 0.91	3.02 ± 2.61*	6.28 ± 4.25***^###
VCAM-1, ng/ml, mean ± SD	151.75 ± 58.21	227.1 ± 96.87*	343.5 ± 181.7***^###
ICAM-1, ng/ml, mean ± SD	30.51 ± 15.83	54.68 ± 42.45*	93.99 ± 55.94***^###
KLF4, pg/ml, mean ± SD	185.47 ± 87.93	350 ± 180.5***	217.4 ± 189.2^##
Infarct volume, ml, mean ± SD	–	7.24 ± 8.36	33.37 ± 30.59^###

Minor stroke was defined as NIHSS score < 7, moderate to severe stroke defined as NIHSS score ≥ 7
ICAM-1 intercellular adhesion molecule-1, KLF4 Kruppel-like factor 4, NIHSS National Institute of Health Stroke Scale, SD standard deviation, VCAM-1 vascular cell adhesion molecule-1
*P < 0.05 vs healthy controls
***P < 0.001 vs healthy controls
^##P < 0.01 vs NIHSS < 7 group
^###P < 0.001 vs NIHSS < 7 group

ISSN: 1742-2094