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Table 2 The comparison of serum levels of three cell adhesion molecules, KLF4, and infarct volume at 48 h after ischemic onset in patients with minor and moderate to severe stroke and healthy controls

From: KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke

VariableControls (n = 33)NIHSS < 7 (n = 39)NIHSS ≥ 7 (n = 35)
E-selectin, ng/ml, mean ± SD1.32 ± 0.913.02 ± 2.61*6.28 ± 4.25***###
VCAM-1, ng/ml, mean ± SD151.75 ± 58.21227.1 ± 96.87*343.5 ± 181.7***###
ICAM-1, ng/ml, mean ± SD30.51 ± 15.8354.68 ± 42.45*93.99 ± 55.94***###
KLF4, pg/ml, mean ± SD185.47 ± 87.93350 ± 180.5***217.4 ± 189.2##
Infarct volume, ml, mean ± SD7.24 ± 8.3633.37 ± 30.59###
  1. Minor stroke was defined as NIHSS score < 7, moderate to severe stroke defined as NIHSS score ≥ 7
  2. ICAM-1 intercellular adhesion molecule-1, KLF4 Kruppel-like factor 4, NIHSS National Institute of Health Stroke Scale, SD standard deviation, VCAM-1 vascular cell adhesion molecule-1
  3. *P < 0.05 vs healthy controls
  4. ***P < 0.001 vs healthy controls
  5. ##P < 0.01 vs NIHSS < 7 group
  6. ###P < 0.001 vs NIHSS < 7 group