Fig. 2

Global transcriptomic changes in HIV-associated minor neurocognitive disorder (MND) relative to controls. a Volcano plot of entire set of detected genes where each point represents the difference in expression (fold change) between MND and CN HIV+ subjects plotted against the levels of statistical significance. Upregulated genes are represented in red, downregulated genes in blue, and top genes in each spectrum are highlighted. b–d Gene ontology enrichment corresponding to cellular components (b) and biological process (c) across the differential genes in MND. Biological pathway analysis of differentially regulated C/EBPβ targets based on REACTOME database (d). The terms are arranged by a number of differentially expressed genes associated to an enriched term and q values where FDR < 0.05 was considered significant. For full list of gene ontology terms and pathways, see Supplementary Tables S2, S3, S6