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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Transcriptomic analysis of brain tissues identifies a role for CCAAT enhancer binding protein β in HIV-associated neurocognitive disorder

Fig. 4

Gene expression is altered in astroglia that overexpress C/EBPβ. a Relative expression of mRNA for C/EBPβ in astrocytes transfected with a control plasmid or a plasmid encoding the C/EBPβ gene. b Immunoblot for C/EBPβ using whole lysates from control astrocytes and astrocytes overexpressing the C/EBPβ gene. c Quantification of densitometry of the ~ 42 kDa band corresponding to C/EBPβ protein. d Relative expression of mRNA for DNM1L in astrocytes transfected with a control plasmid or a plasmid encoding the C/EBPβ gene. e Immunoblot for DNM1L using whole lysates from control astrocytes and astrocytes overexpressing C/EBPβ gene. f Quantification of densitometry of the ~ 90 kDa band corresponding to DNM1L protein. gi Relative mRNA expression levels for IRAK1, BCL11B, and PINK1 in astroglia transfected with control plasmid of pC/EBPβ. Statistical significance was determined by an unpaired t test (*p < 0.05, **p < 0.01, ****p < 0.0001)

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