Fig. 2From: Microglial physiological properties and interactions with synapses are altered at presymptomatic stages in a mouse model of Huntington’s disease pathologyMicroglial morphometric changes observed in the striatum over the course of HD pathology. Picture example showing microglial morphology captured by brightfield microscopy in WT mice at 3 weeks (a), 10 weeks (b), and 12 weeks (c) of age and R6/2 (HTT) mice at 3 weeks (d), 10 weeks (e), and 13 weeks (f) of age, identified using anti-IBA1 staining. Scale bar = 5 μm. Quantitative analysis of microglial cell body area (g), arborization area (h), and morphological index (i) performed at all three ages in both WT and HTT conditions. N = 4 animals per condition. Asterisk denotes the difference from WT, blue number sign denotes the difference between ages in WT mice, red number sign denotes the difference between ages in R6/2 mice; *,#p < 0.05, ###p < 0.001, ####p < 0.0001Back to article page