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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Microglial physiological properties and interactions with synapses are altered at presymptomatic stages in a mouse model of Huntington’s disease pathology

Fig. 6

Microglia-synapse interactions in the dorsomedial striatum during HD pathology. Microglial processes from 3-week-old WT (A) and R6/2 (B), as well as 10-week-old WT (C) and R6/2 (D) mice displaying IBA1+ immunoreactivity and contacting synaptic structures. Proportion of microglial processes making contact with excitatory synaptic clefts (E) as well as the number of synaptic cleft contacts per process (F) was calculated. Microglial process interaction with presynaptic axon terminals (G) and postsynaptic dendritic spines (H) was also determined. Annotations are as follows: d, dendrite; ma, myelinated axon; s, dendritic spine; t, axon terminal. Black arrows denote excitatory synaptic clefts. Scale bar = 500 nm. n = 70–100 microglial processes per animal for all conditions, N = 3–4 animals per condition. Asterisk denotes the difference from WT, blue number sign denotes the difference between ages in WT mice, red number sign denotes difference between ages in R6/2 mice; *p < 0.05, **p < 0.01, ***p < 0.001, ****,####p < 0.0001

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