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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Normalization of magnesium deficiency attenuated mechanical allodynia, depressive-like behaviors, and memory deficits associated with cyclophosphamide-induced cystitis by inhibiting TNF-α/NF-κB signaling in female rats

Fig. 4

TNF-α/NF-κB signaling and IL-1β were upregulated in the SDH and hippocampus of the CYP-induced cystitis model. ac Western blot analysis results indicate that TNF-α, the phospho-p65 (p-p65)/p65 ratio, and IL-1β were increased in the SDH of the CYP-induced cystitis model at all three time points (days 8, 12, and 20) after CYP injection. df TNF-α, the p-p65/p65 ratio, and IL-1β also showed higher expression in the hippocampus of the cystitis group than in the Veh group at the three time points. *P < 0.05, **P < 0.01, and ***P < 0.001 vs. Veh group. The data were analyzed by one-way ANOVA followed by the Tukey post hoc test

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