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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Normalization of magnesium deficiency attenuated mechanical allodynia, depressive-like behaviors, and memory deficits associated with cyclophosphamide-induced cystitis by inhibiting TNF-α/NF-κB signaling in female rats

Fig. 7

Inhibition of NF-κB signaling attenuated mechanical allodynia, depressive-like behavior, and STMD in CYP-induced cystitis model. a Intrathecal injection of pyrrolidinedithiocarbamate ammonium (PDTC), an inhibitor of NF-κB signaling, substantially attenuated mechanical allodynia from day 12 after the first CYP injection. After day 15, the mechanical withdrawal threshold of the CYP + PDTC group became non-significantly different from that of the vehicle group. The data were analyzed by two-way ANOVA followed by the Tukey post hoc test. b Treatment with PDTC significantly reversed the depressive-like behavior of cystitis rats, indicated by a longer floating time in the FST. c The recognition index in the NORT was reduced in cystitis rats, which was normalized by PDTC treatment. The data in band c were analyzed by one-way ANOVA followed by the Tukey post hoc test. n = 7 per group in the von Frey test. n = 5 per group in the FST and NORT. **P < 0.01 and ***P < 0.001 vs. Veh group. ##P < 0.01 and ###P < 0.001 vs. CYP group

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