Fig. 4
From: NK cell-derived exosomes carry miR-207 and alleviate depression-like symptoms in mice
Microarray analysis and exosomal miR-207 uptake by astrocytes. a Forty highly expressed miRNAs in NK cell-derived exosomes from unstressed mice compared with those from stressed mice. Data are presented in a heatmap (n = 3). b Venn diagram of miRNAs of the top 10 GO analyses, top 10 most expressed miRNAs and miRNAs of the top 10 KEGG analyses. c Venn diagram of miR-207 target gene analysis using microRNAorg, PITA and TargetScan databases. d Exosomal miR-207 was taken up by astrocytes. NK cells transfected with a Cy3’-labeled miR-207 mimic were cocultured with astrocytes in a transwell plate with membrane pores of 3 μm (***P < 0.001 vs. mimic NC group; n = 6; bar = 50 μm).