Fig. 4
From: Loss of mural cell-derived laminin aggravates hemorrhagic brain injury
Loss of mural cell-derived laminin exacerbates transcellular transport after ICH. a TEM images showing the ultrastructure of the BBB in control and PKO mice from sham group or at day 2 and day 5 after ICH. Arrows indicate tight junctions and stars indicate pinocytotic vesicles. AE, astrocytic endfeet; BM, basement membrane; E, endothelial cell; L, lumen; P, pericyte; TJ, tight junction. b, c Representative western blots (b) and quantifications (c) of caveolin-1, claudin-5, and ZO-1 expression in endothelial cells after in vitro ICH. *p < 0.05, compared to controls (Student’s t test), n = 6. d Representative images of caveolin-1 staining in control and PKO brains at day 2 after ICH. e Quantification of caveolin-1 intensity in control and PKO brains at day 2 after ICH. ***p < 0.001, compared to the control (Student’s t test), n = 3. Data are shown as mean ± SD