Fig. 9
From: Mitigation of helium irradiation-induced brain injury by microglia depletion
PLX5622 treatment normalizes PSD-95 expression following 4He irradiation. a–c Exposure to 4He irradiation (30 cGy + Con chow) leads to increased expression of PSD-95 puncta (red, nuclear counter stain, DAPI, blue) in the CA1 stratum radiatum compared to controls (*p < 0.05, **p < 0.01; 0 Gy + PLX5622 and 0 Gy + Con chow, respectively). Treatment with PLX5622 reduced PSD-95 expression in the 4He-irradiated brain (*p < 0.05). Data are presented as mean ± SEM (n = 4–6 per group). p values are derived from two-way ANOVA and Bonferroni’s multiple comparisons test. *p < 0.05 and **p < 0.01 compared with the 30 cGy + Con chow group. Scale bar, 40 μm, a–c