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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: IRE1α inhibition attenuates neuronal pyroptosis via miR-125/NLRP1 pathway in a neonatal hypoxic-ischemic encephalopathy rat model

Fig. 3

Effect of intranasal administration of STF083010 on brain infarct volume, neuronal degeneration, neurological function and the relative miR-125-b-2-3p expression level. a Representative TTC staining photographs. b Analysis of infarct volume. c Analysis of reflex time in Geotaxis test. d Representative Fluoro-Jade C staining (FJC) photographs. Left panel indicates the location of microphotographs (small black box). The white box at right upper corner in each FJC staining photographs is the magnification of that at left lower corner. Scale bar = 100 μm. e Analysis of the number of FJC-positive neurons in the FJC staining photographs. f Quantitative analysis of the relative expression level of miR-125b-2-3p in real time PCR tests. Data are represented as means ± SD. n = 6 for each group. *P < 0.05 vs. sham group; @P < 0.05 vs. HI + vehicle group

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Journal of Neuroinflammation

ISSN: 1742-2094