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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Maternal high-fat diet induces sex-specific changes to glucocorticoid and inflammatory signaling in response to corticosterone and lipopolysaccharide challenge in adult rat offspring

Fig. 10

Maternal high-fat diet induces sex-specific effects on transcript responses to CORT + LPS challenge in adulthood. CORT diffuses into the cytosol and binds to glucocorticoid receptor (GR). The CORT-GR complex facilitates the expression of anti-inflammatory molecules including IGF1, MKP1, and I κBα, which at basal levels inhibit pro-inflammatory expression of NFκB, IL6, and CD11B induced by LPS signalling to toll-like receptor 4 (TLR4) and mitogen-activated protein (MAP) kinases. However, with higher levels of CORT, anti-inflammatory effects are reduced, leading to an overall increase in pro-inflammation. In the current study, females exhibited increased MKP1 and a lower IL6/IL10 ratio, while males showed increased NFκB transcript in response to maternal HFD (indicated by arrows)

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Journal of Neuroinflammation

ISSN: 1742-2094