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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Maternal high-fat diet induces sex-specific changes to glucocorticoid and inflammatory signaling in response to corticosterone and lipopolysaccharide challenge in adult rat offspring

Fig. 8

Transcript response to CORT+LPS in the amygdala and hippocampus of adult males. a, b Heatmaps represent transcript levels in the amygdala and hippocampus for individual animals. c–g Relative transcript abundance of GR (glucocorticoid receptor), MR (mineralocorticoid receptor), NFκB (nuclear factor kappa light chain enhancer of activated B cells), the ratio of pro versus anti inflammation designated by IL6/IL10 (interleukin 6/10), and IGF1 expression in the amygdala. h–k Relative transcript abundance of GR, IκBα, IL6/IL10 ratio, and MKP1 in the hippocampus. Data presented are means ± standard error. n = 6/experimental group. Main effect of challenge: *p < 0.05. Main effect of diet: **p < 0.05. Diet/challenge interaction: ***p < 0.05. Scheffe post hoc testing was used for pairwise comparisons (p < 0.05)

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Journal of Neuroinflammation

ISSN: 1742-2094