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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Maternal high-fat diet induces sex-specific changes to glucocorticoid and inflammatory signaling in response to corticosterone and lipopolysaccharide challenge in adult rat offspring

Fig. 9

Transcript response to CORT+LPS in the prefrontal cortex of adult females and males. a, b Heatmaps represent transcript levels in the PFC for individual female and male animals. c–f Relative transcript abundance of NFκB (nuclear factor kappa light chain enhancer of activated B cells), IκBα (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha), IL6 (interleukin 6), and MKP1 (mitogen activated protein kinase phosphatase 1) in the PFC of females. g–j Relative transcript abundance of GR, NFκB, IκBα, and MKP1 in the PFC of males. Data presented are means ± standard error. n = 6/experimental group. Main effect of challenge: *p < 0.05. Main effect of diet: **p < 0.05. Diet/challenge interaction: ***p < 0.05. Scheffe post hoc testing was used for pairwise comparisons (p < 0.05)

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