Fig. 1

In silico analysis of L-VGCC active site and pharmacophore features. The L-VGCC protein model of the active site (red) and their key amino acids from different angles 0°, 90°, 180°, and 270° (a). The pharmacophore model incorporated six features: two hydrogen bond donors (green color) and four hydrophobic groups (yellow color) (b). The location of hydrophobic regions and hydrogen bond donors (c). The Zinc20268761 (d), Zinc18204217 (e), Zinc33254827 (f), and reference Zinc19796041 (Amlodipine) (g), compounds binding with L-VGCC active site (h) residues