Skip to main content
Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Discovery of novel L-type voltage-gated calcium channel blockers and application for the prevention of inflammation and angiogenesis

Fig. 2

Detection of Ca2+ signals and capacitance in BV-2 cells with and without an L-VGCC blockade. Fura-2 Ca2+ signals in untreated BV-2 cells used as the negative control (a). Amlodipine treated BV-2 cells used as the positive control (b). Amlodipine treated HEK293T cells used as assay specificity control (c). BV-2 cells treated with Zinc20267861 (d), Zinc18204217 (e), and Zinc33254827 (f). Electric cell-substrate impedance sensing (ECIS) evaluation of resistance (4 kHz) (g) and capacitance (16 kHz) (h) in BV-2 cells treated with Zinc20267861, Zinc18204217, Zinc33254827, and amlodipine 10 μM; 10% DMSO in PBS 5 μl/ml used as control over the 4-h period (n = 4)

Back to article page