TY - JOUR AU - Jiao, Haihan AU - Downie, Laura E. AU - Huang, Xin AU - Wu, Mengliang AU - Oberrauch, Sara AU - Keenan, Ryan J. AU - Jacobson, Laura H. AU - Chinnery, Holly R. PY - 2020 DA - 2020/04/28 TI - Novel alterations in corneal neuroimmune phenotypes in mice with central nervous system tauopathy JO - Journal of Neuroinflammation SP - 136 VL - 17 IS - 1 AB - Tauopathy in the central nervous system (CNS) is a histopathological hallmark of frontotemporal dementia (FTD) and Alzheimer’s disease (AD). Although AD is accompanied by various ocular changes, the effects of tauopathy on the integrity of the cornea, which is densely innervated by the peripheral nervous system and is populated by resident dendritic cells, is still unknown. The aim of this study was to investigate if neuroimmune interactions in the cornea are affected by CNS tauopathy. SN - 1742-2094 UR - https://doi.org/10.1186/s12974-020-01803-7 DO - 10.1186/s12974-020-01803-7 ID - Jiao2020 ER -