Fig. 7

Parametric distribution volume (V_T) images of [¹¹C]MC1 uptake in monkey 3 before lipopolysaccharide (LPS) injection (top row), on day 1 after the second (LPS) injection (middle row), and after blockade by cold MC1 (1 mg/kg, i.v., bottom row). Orthogonal cross-hairs show the injection site, right putamen. [¹¹C]MC1 uptake was markedly increased near the injection area in the right putamen after LPS injection. Cold MC1 blocked radioligand binding to cyclooxygenase-2 (COX-2) at the injection site to a level lower than that in the remainder of brain. Because this dose of MC1 achieved almost complete blockade (i.e., 75%), the residual uptake closely reflected nondisplaceable distribution volume (V_ND). Thus, V_ND in the area of the lesion was reduced below that of normal brain