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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study

Fig. 9

Human positron emission tomography (PET) images of cyclooxygenase-2 (COX-2) and translocator protein (TSPO) in patient 1 with rheumatoid arthritis and a healthy control. Increased [11C]MC1 uptake in the bilateral hand joints reflected increased COX-2 binding in Patient 1 compared to the healthy control. TSPO binding represented by [11C]ER176 uptake in the same individuals showed consistent distribution with COX-2 binding in the bilateral hand joints of patient 1. The increased [11C]MC1 uptake in patient 1 with rheumatoid arthritis was blocked by celecoxib

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