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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: LncGBP9/miR-34a axis drives macrophages toward a phenotype conducive for spinal cord injury repair via STAT1/STAT6 and SOCS3

Fig. 1

Alternation of macrophage phenotype during spinal cord injury (SCI). a SCI model was constructed in Balb/c mice as described in M&M section. n = 5 in each group. The content and distribution of M1 macrophage marker CD16/32 and M2 macrophage marker Arg1 in spinal cords of sham mice (28 day after sham operation) and SCI mice were examined by Immunofluorescence (IF) staining on days 1, 3, 7, 14, and 28 after treatment. b The mRNA expression and c the protein levels of M1 macrophage markers CD16, iNOS, and IFN-γ and M2 macrophage markers Arg1, CD206, and IL-4 were examined by real-time PCR (n = 5) and immunoblotting in sham group (28 days after sham operation) or SCI group days 1, 3, 7, 14, and 28 after treatment. n = 3. d The BMS scores in sham group or SCI group days 1, 3, 7, 14, and 28 after treatment were determined. (n = 5). *P < 0.05, **P < 0.01

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