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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Spinal cord NLRP1 inflammasome contributes to dry skin induced chronic itch in mice

Fig. 4

TRPV1 is involved in NLRP1 inflammasome mediated chronic itch induced by AEW. a The scheme of AAV-shRNA infusion, capsazepine(CPZ)treatment and AEW-induced dry skin itch. b Representative immunoreactive bands and statistical results showing Nlrp1 knockdown reduced AEW-induced increase in the expression of TRPV1, n = 6. c Statistical results showing CPZ (i.t., 10 μg/site) reduced AEW-induced increase in the number of spontaneous scratches, n = 10. dg Statistical results showing CPZ (i.t., 10 μg/site) inhibited AEW-induced increase in the content of IL-1β, IL-18, IL-6, and TNF-α in the spinal cord, n = 4. Data are expressed as means ± SEM, *P < 0.05 and **P<0.01 vs control group; #P < 0.05 or ##P < 0.01 vs AEW group.

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