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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Spinal cord NLRP1 inflammasome contributes to dry skin induced chronic itch in mice

Fig. 5

Effects of age on AEW-induced chronic itch model. a The scheme of experiments with AEW-induced dry skin itch. b Statistical results showing AEW treatment induced more significant scratching behavior in elderly mice than in young mice, n = 10. ce Representative immunoreactive bands and statistical results showing AEW treatment induced more significant increases in the protein expression of NLRP1, ASC, and caspase-1 in elderly mice than in young mice, n = 6. fh Statistical results showing AEW treatment induced more significant increases in the mRNA levels of NLRP1, ASC and caspase-1 in elderly mice than in young mice , n = 6. il Statistical results showing AEW treatment induced more significant increases in the content of IL-1β, IL-18, IL-6, and TNF-α in elderly mice than in young mice, n = 4, Data are expressed as means ± SEM, *P < 0.05 and **P < 0.01 vs control group or young group

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