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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Inhibition of mast cell tryptase attenuates neuroinflammation via PAR-2/p38/NFκB pathway following asphyxial cardiac arrest in rats

Fig. 5

APC366 improved short-term neurological deficits after ACA. a Effect of APC366 on neurological deficit score (NDS) at 24, 48, and 72 h and at 7 days after ACA. b Seizure activity at 24 and 48 h after ACA. c Adhesive tape removal at 48 and 72 h after ACA. d T-maze test at 7 days after ACA. ACA was associated with significantly worse neurologic functions compared to the shams in all tests except 7-day NDS. APC366 treatment at both doses of 50 μg and 150 μg improved NDS at 24, 48, and 72 h after ACA compared to the vehicle-treated ACA rats. APC366 at dose of 50 μg significantly reduced the seizure activity and improved performance of adhesive tape removal and T-maze tests compared to the ACA + vehicle group. PAR-2 activation with AC55541 exacerbated ACA-induced neurobehavioral deficits in all neurobehavioral tests except for the seizure activity at 24 h and adhesive tape removal at 72 h after ACA. Data are expressed as mean ± SD. n = 6/group. ANOVA, Tukey. **p < 0.001 compared to sham, *p < 0.05 compared to sham, &&p < 0.001 compared to ACA + vehicle, &p < 0.05 compared to ACA + vehicle

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