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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Inhibition of mast cell tryptase attenuates neuroinflammation via PAR-2/p38/NFκB pathway following asphyxial cardiac arrest in rats

Fig. 8

APC366 improved reduced hippocampal neuronal degeneration at 28 days after ACA. a Representative Fluoro-Jade C (FJC) staining microphotographs. b The number of FJC-positive cells in the (a) hippocampal subiculum, (b) CA1, and (c) CA2/3 at 28 days after ACA. Scale bar = 50 μm. APC366 significantly decreased neuronal degeneration in the hippocampal subiculum, CA1, and CA2/3 regions compared to the ACA + vehicle group at 28 days following ACA. Data are expressed as mean ± SD. n = 6/group. ANOVA, Tukey. **p < 0.001 compared to sham, *p < 0.05 compared to sham, &&p < 0.001 compared to ACA + vehicle

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Journal of Neuroinflammation

ISSN: 1742-2094