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Table 1 Experiment 1: Comparison of corneal nerve parameters and immune cell densities in eyes with different topical treatments after 1 week

From: The neuroregenerative effects of topical decorin on the injured mouse cornea

 Main effectsInteractions
DecorinFluid gelContralateral eye effectDecorin # GelGel # Contralateral
Contrast (95% CI)p valueContrast (95% CI)p valueContrast (95% CI)p valuep valuep value
Central cornea        
 SNT (μm)402.1 (49.0, 755.2)0.027277.0 (− 125.3, 679.3)0.166− 103.2 (− 456.4, 249.9)0.5520.8400.249
 SBNP (μm)1350.0 (427.3, 2272.7)0.006152.9 (− 871.6, 1177.3)0.758159.6 (− 763.1, 1082.3)0.7250.1550.687
 DCs (cells/mm2)0.3 (− 1.9, 2.6)0.781− 1.8 (− 4.2, 0.6)0.1380.0 (− 2.3, 2.2)0.9680.3010.469
 Macrophages (cells/mm2)− 72.6 (− 109.2, − 36.1)< 0.00116.1 (− 25.7, 58.0)0.430− 52.0 (− 88.5, − 15.4)0.0070.9250.787
 Ki67+ (cells/mm2)265.1 (− 126.9, 657.0)0.177− 22.6 (− 446.2, 401.0)0.912− 41.2 (− 433.2, 350.7)0.8310.1030.557
Peripheral cornea        
 SNT (μm)109.9 (− 181.4, 401.2)0.446221.5 (− 102.0, 545.0)0.168− 26.5 (− 317.8, 264.8)0.8530.2530.801
 SBNP (μm)475.4 (− 706.4, 1657.2)0.414413.9 (− 958.6, 1786.5)0.535149.5 (− 1032.3, 1331.3)0.7960.5300.851
 DCs (cells/mm2)0.0 (− 3.9, 4.0)0.9840.9 (− 3.5, 5.3)0.670− 1.3 (− 5.2, 2.7)0.5230.1080.713
 Macrophages (cells/mm2)− 45.7 (− 70.9, − 20.4)0.00114.7 (− 13.5, 43.0)0.288− 42.9 (− 68.1, − 17.6)0.0020.8550.695
 Ki67+ (cells/mm2)63.6 (− 253.2, 380.5)0.684− 150.3 (− 495.8, 195.2)0.37383.2 (− 233.7, 400.0)0.5950.2240.095
Corneal thickness at apex        
 Epithelium (μm)0.7 (− 1.0, 2.4)0.4001.3 (− 0.6, 3.3)0.1701.1 (− 0.6, 2.9)0.1930.9100.727
 Stroma (μm)0.2 (− 2.6, 3.1)0.868− 1.8 (− 5.1, 1.5)0.2591.7 (− 1.2, 4.6)0.2310.1890.054
  1. Statistics are derived from a mixed-effects model. Data are also shown in Figs. 2, 3 and Supplemental file Fig. S3. P value indicates the significance of the contrast between the eyes with or without the intervened effect (decorin, fluid gel and etc.)
  2. CI confidence interval, DCs dendritic cells, SBNP Sub-basal nerve plexus, SNT superficial nerve terminals