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Table 1 Experiment 1: Comparison of corneal nerve parameters and immune cell densities in eyes with different topical treatments after 1 week

From: The neuroregenerative effects of topical decorin on the injured mouse cornea

  Main effects Interactions
Decorin Fluid gel Contralateral eye effect Decorin # Gel Gel # Contralateral
Contrast (95% CI) p value Contrast (95% CI) p value Contrast (95% CI) p value p value p value
Central cornea         
 SNT (μm) 402.1 (49.0, 755.2) 0.027 277.0 (− 125.3, 679.3) 0.166 − 103.2 (− 456.4, 249.9) 0.552 0.840 0.249
 SBNP (μm) 1350.0 (427.3, 2272.7) 0.006 152.9 (− 871.6, 1177.3) 0.758 159.6 (− 763.1, 1082.3) 0.725 0.155 0.687
 DCs (cells/mm2) 0.3 (− 1.9, 2.6) 0.781 − 1.8 (− 4.2, 0.6) 0.138 0.0 (− 2.3, 2.2) 0.968 0.301 0.469
 Macrophages (cells/mm2) − 72.6 (− 109.2, − 36.1) < 0.001 16.1 (− 25.7, 58.0) 0.430 − 52.0 (− 88.5, − 15.4) 0.007 0.925 0.787
 Ki67+ (cells/mm2) 265.1 (− 126.9, 657.0) 0.177 − 22.6 (− 446.2, 401.0) 0.912 − 41.2 (− 433.2, 350.7) 0.831 0.103 0.557
Peripheral cornea         
 SNT (μm) 109.9 (− 181.4, 401.2) 0.446 221.5 (− 102.0, 545.0) 0.168 − 26.5 (− 317.8, 264.8) 0.853 0.253 0.801
 SBNP (μm) 475.4 (− 706.4, 1657.2) 0.414 413.9 (− 958.6, 1786.5) 0.535 149.5 (− 1032.3, 1331.3) 0.796 0.530 0.851
 DCs (cells/mm2) 0.0 (− 3.9, 4.0) 0.984 0.9 (− 3.5, 5.3) 0.670 − 1.3 (− 5.2, 2.7) 0.523 0.108 0.713
 Macrophages (cells/mm2) − 45.7 (− 70.9, − 20.4) 0.001 14.7 (− 13.5, 43.0) 0.288 − 42.9 (− 68.1, − 17.6) 0.002 0.855 0.695
 Ki67+ (cells/mm2) 63.6 (− 253.2, 380.5) 0.684 − 150.3 (− 495.8, 195.2) 0.373 83.2 (− 233.7, 400.0) 0.595 0.224 0.095
Corneal thickness at apex         
 Epithelium (μm) 0.7 (− 1.0, 2.4) 0.400 1.3 (− 0.6, 3.3) 0.170 1.1 (− 0.6, 2.9) 0.193 0.910 0.727
 Stroma (μm) 0.2 (− 2.6, 3.1) 0.868 − 1.8 (− 5.1, 1.5) 0.259 1.7 (− 1.2, 4.6) 0.231 0.189 0.054
  1. Statistics are derived from a mixed-effects model. Data are also shown in Figs. 2, 3 and Supplemental file Fig. S3. P value indicates the significance of the contrast between the eyes with or without the intervened effect (decorin, fluid gel and etc.)
  2. CI confidence interval, DCs dendritic cells, SBNP Sub-basal nerve plexus, SNT superficial nerve terminals