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Table 2 Experiment 2: Comparison of immune cell densities in eyes with different topical treatments after 6 h (i.e., 3× doses, 2 h apart)

From: The neuroregenerative effects of topical decorin on the injured mouse cornea

 Main effectsInteractions
DecorinFluid gelContralateral eye effectDecorin # GelGel # Contralateral
Contrast (95% CI)p valueContrast (95% CI)p valueContrast (95% CI)p valuep valuep value
Re-epithelialisation (%)2.4 (− 3.1, 8.0)0.377− 3.9 (− 9.9, 2.1)0.1920.1 (− 5.5, 5.7)0.9770.9820.878
Stromal thickness (μm)− 0.8 (− 9.8, 8.1)0.85416.5 (7.1, 26.0)0.0022.5 (− 6.4, 11.3)0.5730.2040.153
Peripheral cornea        
 DCs (cells/mm2)15.7 (7.6, 23.8)< 0.001− 4.6 (− 13.0, 3.7)0.2613.4 (− 4.7, 11.5)0.4000.2000.248
 DC area (μm2/cell)119.3 (− 68.8, 307.4)0.205− 172.6 (− 369.7, 24.5)0.083137.1 (− 51.0, 325.2)0.1470.4600.302
 Macrophages (cells/mm2)− 6.9 (− 23.4, 9.5)0.396− 0.2 (− 18.0, 17.5)0.977− 10.4 (− 26.9, 6.1)0.2060.1960.832
 Neutrophils (cells/mm2)− 144.5 (− 343.9, 54.9)0.150− 135.4 (− 342.3, 71.5)0.188− 281.1 (− 480.5, − 81.8)0.0070.0710.317
  1. Statistics are derived from mixed-effects models. Data are also shown in Fig. 4 and Supplemental file Fig. S4. P value indicates the significance of the contrast between the eyes with or without the intervened effect (decorin, fluid gel and etc.)
  2. CI confidence interval, DC dendritic cell