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Table 2 Plasma biomarkers predicting stroke and ICH

From: Plasma neurofilament light chain and glial fibrillary acidic protein predict stroke in CADASIL

 Stroke at baselineICH at baselineIncident strokeIncident ICH
 aOR (95% CI)*p valueaOR (95% CI)*p valueHR (95% CI)p valueHR (95% CI)p value
NfL2.02 (1.063.87)0.031.17 (0.76–1.81)0.481.93 (1.193.13)0.012.39 (1.214.70)0.01
GFAP2.51 (0.92–6.89)0.072.06 (1.263.35)0.0041.62 (0.92–2.85)0.092.80 (1.216.53)0.02
Tau1.52 (0.85–2.71)0.151.23 (0.76–1.99)0.400.74 (0.37–1.47)0.391.36 (0.61–3.04)0.45
UCHL11.28 (0.72–2.28)0.391.74 (0.995–3.06)0.051.42 (0.80–2.52)0.231.61 (0.86–3.02)0.14
  1. Numbers in bold indicate statistical significance
  2. aOR adjusted odds ratio, GFAP glial fibrillary acidic protein, HR hazard ratio, ICH intracerebral hemorrhage, NfL neurofilament light chain, UCHL1 ubiquitin carboxy-terminal hydrolase L1
  3. *Logistic regression models adjusted for age, sex, and hypertension. Cox regression models adjusted after age, sex, and history of intracerebral hemorrhage at baseline