Plasma neurofilament light chain and glial fibrillary acidic protein predict stroke in CADASIL

Table 2 Plasma biomarkers predicting stroke and ICH

	Stroke at baseline		ICH at baseline		Incident stroke		Incident ICH
	aOR (95% CI)*	p value	aOR (95% CI)*	p value	HR (95% CI)^†	p value	HR (95% CI)^†	p value
NfL	2.02 (1.06–3.87)	0.03	1.17 (0.76–1.81)	0.48	1.93 (1.19–3.13)	0.01	2.39 (1.21–4.70)	0.01
GFAP	2.51 (0.92–6.89)	0.07	2.06 (1.26–3.35)	0.004	1.62 (0.92–2.85)	0.09	2.80 (1.21–6.53)	0.02
Tau	1.52 (0.85–2.71)	0.15	1.23 (0.76–1.99)	0.40	0.74 (0.37–1.47)	0.39	1.36 (0.61–3.04)	0.45
UCHL1	1.28 (0.72–2.28)	0.39	1.74 (0.995–3.06)	0.05	1.42 (0.80–2.52)	0.23	1.61 (0.86–3.02)	0.14

Numbers in bold indicate statistical significance
aOR adjusted odds ratio, GFAP glial fibrillary acidic protein, HR hazard ratio, ICH intracerebral hemorrhage, NfL neurofilament light chain, UCHL1 ubiquitin carboxy-terminal hydrolase L1
*Logistic regression models adjusted for age, sex, and hypertension. ^†Cox regression models adjusted after age, sex, and history of intracerebral hemorrhage at baseline

ISSN: 1742-2094