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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Microglia knockdown reduces inflammation and preserves cognition in diabetic animals after experimental stroke

Fig. 6

CSF1R KD improved myelination. ac Depicts representative images of GFAP+ cells of slice B for sham, NTC, CSF1R KD animals, respectively. d There was no significant difference in the number of GFAP+ cells in the PFC or limbic structures of slice B and GFAP+ cells. e Depicts representative images of NF200+ and MBP+ cells of slice B for NTC, CSF1R KD, and sham animals, respectively. Using MBP to stain myelin and NF200 to stain the axons, we evaluated the ratio of MBP:NF200 as a measure of myelination (e). Although diabetic animals exhibited demyelination 3 weeks after stroke, CSF1R KD prevented this decline in myelination (N = 5–7/group)

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