Fig. 1
From: Inhibition of formyl peptide receptors improves the outcome in a mouse model of Alzheimer disease
Boc2 treatment of APP/PS1 double-transgenic mice improves spatial memory performance, analyzed by Morris water maze test. The eight-week-old APP/PS1 double-transgenic was injected for a period of 20 weeks with Boc2, fMLF, or Ac2-26. a mean distance to platform (m), (b) corrected integrated path length (m/s), (c) latency (s) time, and (d) path efficiency during the test trials were analyzed. (e) Representative track plot (test trial) of wildtype or APP/PS1 double-transgenic mice without or with Boc2 treatment. APP/PS1 double-transgenic mice showed a significantly worth performance in long-term memory compared to age-matched WT littermates. Boc2 treatment rescued this effect. The entry of the maze was top left and the platform position (small circle) bottom right. Statistical significances were determined using two-way ANOVAs followed by turkey post hoc test. Data represent mean + SEM; n ≥ 14; *p < 0.05, **p < 0.01