TY - JOUR AU - Johnson, M. Brittany AU - Halman, Justin R. AU - Burmeister, Amanda R. AU - Currin, Saralynn AU - Khisamutdinov, Emil F. AU - Afonin, Kirill A. AU - Marriott, Ian PY - 2020 DA - 2020/05/01 TI - Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells JO - Journal of Neuroinflammation SP - 139 VL - 17 IS - 1 AB - Bacterial meningitis and meningoencephalitis are associated with devastating neuroinflammation. We and others have demonstrated the importance of glial cells in the initiation of immune responses to pathogens invading the central nervous system (CNS). These cells use a variety of pattern recognition receptors (PRRs) to identify common pathogen motifs and the cytosolic sensor retinoic acid inducible gene-1 (RIG-I) is known to serve as a viral PRR and initiator of interferon (IFN) responses. Intriguingly, recent evidence indicates that RIG-I also has an important role in the detection of bacterial nucleic acids, but such a role has not been investigated in glia. SN - 1742-2094 UR - https://doi.org/10.1186/s12974-020-01817-1 DO - 10.1186/s12974-020-01817-1 ID - Johnson2020 ER -