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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: The cerebrovascular and neurological impact of chronic smoking on post-traumatic brain injury outcome and recovery: an in vivo study

Fig. 8

Effect of premorbid TS-exposure and TBI on BBB integrity. A Western blotting analysis demonstrating downregulation of TJ proteins Occludin (a), Claudin-5 (b), and accessory anchoring protein ZO-1 (c) in mice exposed to TS and/or TBI. Note that TBI per se had only a marginal impact on the expression levels of claudin-5 and ZO-1. Therefore, with the exclusion of occludin, which was significantly downregulated by TBI, TS seemed mainly responsible for the TJ downregulation observed in TBI mice chronically exposed to cigarette smoke. n = 6 biological replicates for each experimental group. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 vs. control. #p < 0.05, ####p < 0.0001 vs. smoke. @p < 0.05, @@p < 0.01, vs. TBI

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