Table 2 Frequency of intrathecal IgG synthesis, oligoclonal IgG pattern, IgG CSF/serum ratios, intrathecal IgG fractions, absolute amount of locally produced IgG, and absolute IgG concentrations in the CSF and serum

Intrathecal IgG synthesis

 OCB positive or IgG-IF ≥ 10%

Samples

20/151 (13.2%)

13/112 (11.6%)

2/24 (8.3%)

7/50 (14%)

3/51 (5.9%)

2/10 (20%)

 OCB positive

Samples

20/151 (13.2%)

13/112 (11.6%)

2/24 (8.3%)

7/50 (14%)

3/50 (6%)

2/10 (20%)

 OCB pattern 1

Samples

101/150 (67.3%)

77/112 (68.8%)

18/24 (75%)

30/50 (60%)

41/50 (82%)

5/10 (50%)

 OCB pattern 2

Samples

14/150 (9.3%)

9/112 (8%)

2/24 (8.3%)

3/50 (6%)

3/50 (6%)

2/10 (20%)

 OCB pattern 3

Samples

5/150 (3.3%)

4/112 (3.6%)

0/24 (0%)

4/50 (8%)

0/50 (0%)

0/10 (0%)

 OCB pattern 4

Samples

28/150 (18.7%)

20/112 (17.9%)

4/24 (16.7%)

11/50 (22%)

6/50 (12%)

3/10 (30%)

 OCB pattern 5

Samples

2/150 (1.3%)

2/112 (1.8%)

0/24 (0%)

2/50 (4%)

0/50 (0%)

0/10 (0%)

 OCB pattern 2 or 3

Samples

19/150 (12.7%)

13/112 (11.6%)

2/24 (8.3%)

7/50 (14%)

3/50 (6%)

2/10 (20%)

 OCB pattern 3 or 4

Samples

33/150 (22%)

24/112 (21.4%)

4/24 (16.7%)

15/50 (30%)

6/50 (12%)

3/10 (30%)

 OCB pattern 1, 4, or 5

Samples

131/150 (87.3%)

99/112 (88.4%)

22/24 (91.7%)

13/50 (86%)

6/50 (94%)

3/10 (80%)

 QIgG > Q_lim(IgG)

Samples

11/133 (8%)

9/100 (9%)

1/23 (4%)

6/47 (12.8%)

2/44 (4.5%)

1/8 (12.5%)

 QIgG, all LPs

-

3.5 (0.9-23.6; 131)

3.5 (0.9-23.6; 99)

3.2 (1.5-14.7; 23)

4.2 (1.11-23.61; 47)

2.66 (1.32-14.09; 43)

4.24 (0.9-4.96; 8)

 QIgG, if positive

-

4 (2.3-7; 10)

4.5 (2.37; 9)

3.2 (3.2-3.2; 1)

5.92 (2.26-7.01; 6)

4.02 (3.57-4.47; 2)

2.37 (2.37-2.37; 1)

 IgG IF, all LPs

% IgG(CSF)

0 (0-53.3; 131)

0 (0-53.3; 99)

0 (0-6.8; 23)

0 (0-53.3; 47)

0 (0-26.4; 43)

0 (0-1.1; 8)

 IgG IF, QIgG positives

% IgG(CSF)

10.5 (1.13-53.3; 10)

14.2 (1.1-53.3; 9)

6.8 (6.8-6.8; 1)

11.9 (4.5-53.3; 6)

20.3 (14.2-26.4; 2)

1.1 (1.1-1.1; 1)

 IgG IF, > 10%

Samples

5/131 (3.8%)

5/99 (5.1%)

0/23 (0%)

3/47 (6.4%)

2/43 (4.7%)

0/8 (0%)

 IgG Loc, all LPs

mg/l

0 (0-25; 127)

0 (0-25; 96)

0 (0-2.1; 22)

0 (0-25; 45)

0 (0-0.3; 8)

0 (0-25; 96)

 IgG Loc, QIgG positives

mg/l

2.3 (0.29-25; 9)

4.7 (0.3-25; 8)

2.1 (2.1-2.1; 1)

2.3 (1.1-25; 5)

9.7 (7.9-11.6; 2)

0.3 (0.3-0.3; 1)

 IgG CSF, all LPs

mg/l

33.1 (11-236.1; 129)

33.3 (11-236.1; 96)

32.4 (13-182; 22)

39.8 (11-236.1; 45)

28.9 (14.6-121; 42)

27 (17-58; 8)

 IgG CSF, QIgG positives

mg/l

38 (22.5-75.7; 9)

41 (22.5-75.7; 8)

30.9 (30.9-30.9; 1)

38 (22.5-75.7; 5)

49.7 (44-55.4; 2)

25.8 (25.8-25.8; 1)

 IgG serum, all LPs

g/l

9.9 (4-31.8; 127)

9.9 (4-31.8; 96)

9.8 (6-12.4; 22)

9.4 (4-31.8; 45)

10.2 (5.86-23.9; 42)

10.84 (4-31; 8)

 IgG serum, QIgG positives

g/l

10 (6.3-15.5; 9)

10.4 (6.3-15.5; 8)

9.6 (9.6-9.6; 1)

10 (6.3-11.1; 5)

12.7 (9.8-15.5; 2)

10.9 (10.9-10.9; 1)

 Link index, all

Samples

13/131 (10%)

9/99 (9%)

4/23 (17%)

7/47 (14.9%)

2/43 (4.7%)

0/8 (0%)

 Link index, if positive

Index

0.8 (0.7-1.7; 13)

0.8 (0.7-1.5; 9)

1.2 (0.7-1.7; 4)

0.8 (0.7-1.5; 7)

0.9 (0.8-0.9; 2)

n.a. (n.a.; 0)