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Table 2 Frequency of intrathecal IgG synthesis, oligoclonal IgG pattern, IgG CSF/serum ratios, intrathecal IgG fractions, absolute amount of locally produced IgG, and absolute IgG concentrations in the CSF and serum

From: Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 1: Results from 163 lumbar punctures in 100 adult patients

  Units Total Attack Remission Acute MY subgroup Acute ON subgroup Acute BRAIN subgroup
Intrathecal IgG synthesis        
 OCB positive or IgG-IF ≥ 10% Samples 20/151 (13.2%) 13/112 (11.6%) 2/24 (8.3%) 7/50 (14%) 3/51 (5.9%) 2/10 (20%)
 OCB positive Samples 20/151 (13.2%) 13/112 (11.6%) 2/24 (8.3%) 7/50 (14%) 3/50 (6%) 2/10 (20%)
 OCB pattern 1 Samples 101/150 (67.3%) 77/112 (68.8%) 18/24 (75%) 30/50 (60%) 41/50 (82%) 5/10 (50%)
 OCB pattern 2 Samples 14/150 (9.3%) 9/112 (8%) 2/24 (8.3%) 3/50 (6%) 3/50 (6%) 2/10 (20%)
 OCB pattern 3 Samples 5/150 (3.3%) 4/112 (3.6%) 0/24 (0%) 4/50 (8%) 0/50 (0%) 0/10 (0%)
 OCB pattern 4 Samples 28/150 (18.7%) 20/112 (17.9%) 4/24 (16.7%) 11/50 (22%) 6/50 (12%) 3/10 (30%)
 OCB pattern 5 Samples 2/150 (1.3%) 2/112 (1.8%) 0/24 (0%) 2/50 (4%) 0/50 (0%) 0/10 (0%)
 OCB pattern 2 or 3 Samples 19/150 (12.7%) 13/112 (11.6%) 2/24 (8.3%) 7/50 (14%) 3/50 (6%) 2/10 (20%)
 OCB pattern 3 or 4 Samples 33/150 (22%) 24/112 (21.4%) 4/24 (16.7%) 15/50 (30%) 6/50 (12%) 3/10 (30%)
 OCB pattern 1, 4, or 5 Samples 131/150 (87.3%) 99/112 (88.4%) 22/24 (91.7%) 13/50 (86%) 6/50 (94%) 3/10 (80%)
 QIgG > Qlim(IgG) Samples 11/133 (8%) 9/100 (9%) 1/23 (4%) 6/47 (12.8%) 2/44 (4.5%) 1/8 (12.5%)
 QIgG, all LPs - 3.5 (0.9-23.6; 131) 3.5 (0.9-23.6; 99) 3.2 (1.5-14.7; 23) 4.2 (1.11-23.61; 47) 2.66 (1.32-14.09; 43) 4.24 (0.9-4.96; 8)
 QIgG, if positive - 4 (2.3-7; 10) 4.5 (2.37; 9) 3.2 (3.2-3.2; 1) 5.92 (2.26-7.01; 6) 4.02 (3.57-4.47; 2) 2.37 (2.37-2.37; 1)
 IgG IF, all LPs % IgG(CSF) 0 (0-53.3; 131) 0 (0-53.3; 99) 0 (0-6.8; 23) 0 (0-53.3; 47) 0 (0-26.4; 43) 0 (0-1.1; 8)
 IgG IF, QIgG positives % IgG(CSF) 10.5 (1.13-53.3; 10) 14.2 (1.1-53.3; 9) 6.8 (6.8-6.8; 1) 11.9 (4.5-53.3; 6) 20.3 (14.2-26.4; 2) 1.1 (1.1-1.1; 1)
 IgG IF, > 10% Samples 5/131 (3.8%) 5/99 (5.1%) 0/23 (0%) 3/47 (6.4%) 2/43 (4.7%) 0/8 (0%)
 IgG Loc, all LPs mg/l 0 (0-25; 127) 0 (0-25; 96) 0 (0-2.1; 22) 0 (0-25; 45) 0 (0-0.3; 8) 0 (0-25; 96)
 IgG Loc, QIgG positives mg/l 2.3 (0.29-25; 9) 4.7 (0.3-25; 8) 2.1 (2.1-2.1; 1) 2.3 (1.1-25; 5) 9.7 (7.9-11.6; 2) 0.3 (0.3-0.3; 1)
 IgG CSF, all LPs mg/l 33.1 (11-236.1; 129) 33.3 (11-236.1; 96) 32.4 (13-182; 22) 39.8 (11-236.1; 45) 28.9 (14.6-121; 42) 27 (17-58; 8)
 IgG CSF, QIgG positives mg/l 38 (22.5-75.7; 9) 41 (22.5-75.7; 8) 30.9 (30.9-30.9; 1) 38 (22.5-75.7; 5) 49.7 (44-55.4; 2) 25.8 (25.8-25.8; 1)
 IgG serum, all LPs g/l 9.9 (4-31.8; 127) 9.9 (4-31.8; 96) 9.8 (6-12.4; 22) 9.4 (4-31.8; 45) 10.2 (5.86-23.9; 42) 10.84 (4-31; 8)
 IgG serum, QIgG positives g/l 10 (6.3-15.5; 9) 10.4 (6.3-15.5; 8) 9.6 (9.6-9.6; 1) 10 (6.3-11.1; 5) 12.7 (9.8-15.5; 2) 10.9 (10.9-10.9; 1)
 Link index, all Samples 13/131 (10%) 9/99 (9%) 4/23 (17%) 7/47 (14.9%) 2/43 (4.7%) 0/8 (0%)
 Link index, if positive Index 0.8 (0.7-1.7; 13) 0.8 (0.7-1.5; 9) 1.2 (0.7-1.7; 4) 0.8 (0.7-1.5; 7) 0.9 (0.8-0.9; 2) n.a. (n.a.; 0)
  1. Quotients, indices, concentrations, and fractions are given as median and range
  2. QIgG/A/M CSF/serum IgG/A/M ratio, IgG/A/M IF intrathecally produced IgG/IgA/IgM fraction, IgG/A/M loc locally (intrathecally) produced IgG/A/M, LP lumbar puncture