Table 3 Frequency of intrathecal IgM and IgA synthesis, IgM and IgA CSF/serum ratios, intrathecal IgM and IgA fractions, amount of locally produced IgM and IgA, and absolute IgM and IgA concentrations in the CSF and serum

 QIgM > Q_lim(IgM)

Samples

13/112 (12%)

13/84 (15%)

0/20 (0%)

9/38 (24%)

3/39 (8%)

1/6 (17%)

 QIgM, all LPs

-

0.5 (0-13.8; 111)

0.6 (0-13.8; 83)

0.5 (0-4.1; 20)

1.11 (0-13.81; 38)

0.41 (0-1.82; 38)

0.28 (0-1.9; 6)

 QIgM, if positive

-

1.9 (0.6-9.6; 13)

1.9 (0.6-9.6; 13)

n.a.

2.72 (0.63-9.63; 9)

0.84 (0.68-1.33; 3)

1.9 (1.9-1.9; 1)

 IgM IF, all LPs

% IgM (CSF)

0 (0-59.1; 111)

0 (0-59.1; 83)

0 (0-0; 20)

0 (0-59.1; 38)

0 (0-41.9; 38)

0 (0-18.3; 6)

 IgM IF, QIgM positives

% IgM (CSF)

9.2 (1-59.1; 13)

9.2 (1-59.1; 13)

n.a. (n.a.;0)

9.2 (3.5-59.1; 9)

9 (1-41.9; 3)

18.3 (18.3-18.3; 1)

 IgM IF, > 10%

Samples

6/111 (5.4%)

6/83 (7.2%)

0/20 (0%)

4/38 (10.5%)

1/38 (2.6%)

1/6 (16.7%)

 IgM Loc, all LPs

mg/l

0 (0-2.3; 108)

0 (0-2.3; 81)

0 (0-0; 19)

0 (0-2.3; 36)

0 (0-0.3; 38)

0 (0-0.6;6)

 IgM Loc, QIgM positives

mg/l

0.32 (0.01-2.3; 13)

0.32 (0.01-2.3; 13)

n.a.

0.3 (0.1-2.3; 9)

0 (0-0.3; 3)

0.6 (0.6-0.6; 1)

 IgM CSF

mg/l

0.5 (0-16.3; 110)

0.5 (0-16.3; 82)

0.49 (0-3.6; 19)

1.69 (0-16.3; 36)

0.36 (0-1.51; 39)

0.25 (0-4.19; 6)

 IgM serum

g/l

1.02 (0.15-3.73; 112)

1.03 (0.15-3.73; 84)

0.89 (0.39-2.19; 20)

1.18 (0.3-2.96; 37)

0.94 (0.15-2.41; 40)

1 (0.79-3.73; 6)

 QIgA > Q_lim(IgA)

Samples

5/111 (5%)

4/83 (5%)

1/20 (5%)

2/38 (5.3%)

2/38 (5.3%)

0/6 (0%)

 QIgA, all LPs

-

2 (0-17.3; 110)

1.9 (0-17.3; 82)

2.5 (0-11.1; 20)

2.65 (0-17.27; 38)

1.51 (0-3.22; 37)

2.15 (0-3.26; 6)

 QIgA, if positive

-

2.6 (1.7-6.2; 5)

2.4 (1.7-6.2; 4)

2.9 (2.9-2.9; 1)

4.42 (2.61-6.24; 2)

1.96 (1.68_2.24; 2)

n.a. (n.a.; 0)

 IgA IF, all LPs

% IgA (CSF)

0 (0-34.2; 110)

0 (0-31.7; 82)

0 (0-34.2; 20)

0 (0-31.7; 38)

0 (0-13.3; 37)

0 (0-0; 6)

 IgA IF, QIgA positives

% IgA (CSF)

13.3 (3.8-34.2; 5)

9.5 (3.8-31.7; 4)

34.2 (34.2-34.2; 1)

17.8 (3.8-31.7; 2)

9.5 (5.7-13.3; 2)

n.a. (n.a.; 0)

 IgA IF, > 10%

Samples

3/110 (2.7%)

2/82 (2.4%)

1/20 (5%)

1/38 (2.6%)

1/37 (2.7%)

0/6 (0%)

 IgA Loc, all LPs

mg/l

0 (0-2.9; 106)

0 (0-2.9; 79)

0 (0-2; 19)

0 (0-2.9;36)

0 (0-0.5; 36)

0 (0-0; 6)

 IgA Loc, QIgA positives

mg/l

0.5 (0.2-2.9; 5)

0.5 (0.2-2.9; 4)

2 (2-2; 1)

1.6 (0.4-2.9; 2)

0.4 (0.2-0.5; 2)

n.a. (n.a.; 0)

 IgA CSF

mg/l

3.6 (0-40.7; 109)

3.57 (0-40.7; 81)

4.4 (0-29.1; 19)

4.34 (0-40.7; 36)

3.1 (0-7.99; 38)

3.4 (0-10.4; 6)

 IgA serum

g/l

1.95 (0.25-7; 108)

1.8 (0.62-7; 81)

2.3 (1.1-3; 19)

1.77 (0.62-7; 37)

2.04 (0.73-5.16; 37)

1.94 (0.67-3.99; 6)