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Table 6 Blood CSF barrier function, CSF total protein and CSF L-lactate in MOG-IgG-positive EM

From: Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 1: Results from 163 lumbar punctures in 100 adult patients

  Units Total Attack Remission Acute MY subgroup Acute ON subgroup Acute BRAIN subgroup
Blood-CSF barrier function
 QAlb > QAlb(lim) Samples 67/139 (48.2%) 49/105 (46.7%) 10/23 (43.5%) 28/50 (56%) 16/46 (34.8%) 4/8 (50%)
 QAlb, all LPs - 6.6 (3-32.7; 138) 6.4 (3-32.7; 105) 6 (3.1-18.5; 23) 7.4 (3.1-32.7; 50) 5.4 (3-26.3; 46) 7.8 (3.6-8.9; 8)
 QAlb, if positive - 9.6 (5.5-32.67; 66) 9.2 (5.5-32.67; 49) 11.8 (8.08-18.51; 10) 10.8 (6.4-32.7; 28) 7.8 (5.5-26.3; 16) 8 (6.8-8.9; 4)
 Alb CSF mg/l 273 (123-1260; 131) 261.5 (123-1260; 98) 280 (123-694; 22) 305 (133-1038.9; 46) 218 (123-1260; 43) 310 (175-371; 8)
 Alb serum g/l 42.1 (25.9-50.6; 126) 42.15 (25.9-50.6; 94) 41.8 (33.5-49.8; 22) 42.2 (25.9-50.6; 46) 42.2 (32.4-50.4; 39) 41.9 (37.3-48.7; 8)
 Albumin-cellular dissociation Samples 23/67 (34.3%) 14/49 (28.6%) 4/10 (40%) 2/28 (7.1%) 11/16 (68.8%) 1/4 (25%)
 Combined BCB disruption
 and intrathecal IgG synthesis Samples 12/67 (17.9%) 8/49 (16.3%) 1/10 (10%) 6/28 (21.4%) 1/16 (6.3%) 1/4 (25%)
CSF total protein
 CSF TP, elevated Samples 64/146 (43.8%) 49/110 (44.5%) 9/25 (36%) 27/51 (52.9%) 16/50 (32%) 6/8 (75%)
 CSF TP, all LPs mg/dl 43.75 (5.11-176; 136) 43.75 (20.4-176; 102) 40 (5.11-148; 23) 49.6 (20.5-176; 48) 37.2 (20.4-171.8; 46) 48.2 (30.4-74.2; 8)
 CSF TP, if elevated mg/dl 64.65 (45.3-176; 64) 65 (45.3-176; 49) 61.9 (47-148; 9) 73.3 (46.7-176; 27) 60.4 (45.3-171.8; 16) 50.7 (47-74.2; 6)
 CSF TP, > 100 mg/dl Samples 11/136 (8.1%) 8/102 (7.8%) 2/23 (8.7%) 7/48 (14.6%) 1/46 (2.2%) 0/0 (0%)
CSF l-lactate
 CSF l-lactate, elevated Samples 28/107 (26.2%) 25/79 (31.6%) 1/20 (5%) 18/37 (48.6%) 7/39 (17.9%) 0/3 (0%)
 CSF l-lactate, all LPs mmol/l 1.8 (1.05-4.43; 103) 1.9 (1.05-4.43; 76) 1.7 (1.33-2.4; 19) 2.31 (1.12-4.43; 35) 1.75 (1.05-2.68; 38) 1.51 (1.5-1.7; 3)
 CSF L-lactate, if elevated mmol/l 2.68 (2.1-4.43; 28) 2.68 (2.1-4.43; 25) 2.4 (2.4-2.4; 1) 2.53 (1.88-4.43; 20) 1.7 (1.05-2.68; 10) 1.51 (1.5-1.51; 2)
 CSF l-lactate, >3 mmol/l Samples 10/103 (9.7%) 8/76 (10.5%) 0/19 (0%) 8/35 (22.9%) 0/38 (0%) 0/3 (0%)
  1. Ratios and concentrations are given as median (with ranges and sample numbers in brackets)
  2. Alb albumin; BCB blood–CSF barrier; LP lumbar puncture; QAlb CSF/serum albumin ratio; TP total protein