Table 2 Frequency of intrathecal IgG synthesis, oligoclonal IgG pattern, IgG CSF/serum ratios, intrathecal IgG fractions, absolute amount of locally produced IgG, and absolute IgG concentrations in the CSF and serum

 OCB positive or IgG-IF ≥ 10%

Samples

14/97 (14.4%)

14/87 (16.1%)

0/8 (0%)

8/28 (28.6%)

0/27 (0%)

6/32 (18.8%)

 OCB positive

Samples

11/96 (11.5%)

11/86 (12.8%)

0/8 (0%)

7/28 (25%)

0/26 (0%)

4/31 (12.9%)

 OCB pattern 1

Samples

77/96 (80.2%)

68/86 (79.1%)

7/8 (87.5%)

19/28 (67.9%)

24/26 (92.3%)

24/31 (77.4%)

 OCB pattern 2

Samples

7/96 (7.3%)

7/86 (8.1%)

0/8 (0%)

6/28 (21.4%)

0/26 (0%)

1/31 (3.2%)

 OCB pattern 3

Samples

4/96 (4.2%)

4/86 (4.7%)

0/8 (0%)

1/28 (3.6%)

0/26 (0%)

3/31 (9.7%)

 OCB pattern 4

Samples

7/96 (7.3%)

6/86 (7%)

1/8 (12.5%)

2/28 (7.1%)

2/26 (7.7%)

2/31 (6.5%)

 OCB pattern 5

Samples

1/96 (1%)

1/86 (1.2%)

0/8 (0%)

0/28 (0%)

0/26 (0%)

1/31 (3.2%)

 OCB pattern 2 or 3

Samples

11/96 (11.5%)

11/86 (12.8%)

0/8 (0%)

7/28 (25%)

0/26 (0%)

4/31 (12.9%)

 OCB pattern 3 or 4

Samples

11/96 (11.5%)

10/86 (11.6%)

1/8 (12.5%)

3/28 (10.7%)

2/26 (7.7%)

5/31 (16.1%)

 OCB pattern 1, 4, or 5

Samples

85/96 (88.5%)

75/86 (87.2%)

8/8 (100%)

2/28 (75%)

2/26 (100%)

3/31 (87.1%)

 QIgG > Q_lim(IgG)

Samples

14/78 (18%)

13/69 (19%)

0/7 (0%)

8/23 (34.8%)

1/21 (4.8%)

4/25 (16%)

 QIgG, all LPs

–

2.3 (0.8–8.2; 76)

2.4 (0.8–8.2; 68)

1.6 (1.3–1.7; 6)

3.13 (0.83–8.06; 22)

1.61 (0.84–8.16; 20)

2.3 (0.95–7.94; 26)

 QIgG, if positive

–

2.4 (1.5–7; 14)

2.4 (1.5–7; 13)

n.a. (n.a.; 0)

2.64 (1.79–6.97; 8)

1.53 (1.53–1.53; 1)

2.3 (1.66–4.22; 4)

 IgG IF, all LPs

%IgG_CSF

0 (0-27; 75)

0 (0-27; 67)

0 (0-0; 6)

0 (0-13.2; 22)

0 (0-4.4; 20)

0 (0-27; 25)

 IgG IF, QIgG pos

%IgG_CSF

7.6 (0.03–27; 14)

7.8 (0–27; 13)

n.a. (n.a.; 0)

7.6 (0–13.2; 8)

4.4 (4.4–4.4; 1)

17.9 (4–27; 4)

 IgG IF, > 10%

Samples

6/75 (8%)

6/67 (9%)

0/6 (0%)

3/22 (13.6%)

0/20 (0%)

3/25 (12%)

 IgG Loc, all LPs

mg/l

0 (0–15.4; 75)

0 (0–15.4; 67)

0 (0–0; 6)

0 (0–4.8; 22)

0 (0–15.4; 25)

0 (0–15.4; 67)

 IgG Loc, QIgG pos

mg/l

2.4 (0–15.4; 14)

2.5 (0–15.4; 13)

n.a. (n.a.; 0)

2.7 (0–4.8; 8)

0.6 (0.6–0.6; 1)

3.8 (0.9–15.4; 4)

 IgG CSF, all LPs

mg/l

21.6 (5.4–107; 79)

24.6 (5.4–107; 71)

14.8 (10–21.6; 6)

37.6 (5.7–107; 22)

15.1 (5.4–72.6; 20)

22.8 (9–79.9; 29)

 IgG CSF, QIgG pos

mg/l

22.5 (13.7–74.3; 14)

22.8 (13.7–74.3; 13)

n.a. (n.a.; 0)

27.9 (20–74.3; 8)

13.7 (13.7–13.7; 1)

22.5 (19–57; 4)

 IgG serum, all LPs

g/l

9.6 (3.1–46.9; 78)

9.9 (3.1–46.9; 70)

9 (6.3–13.9; 6)

10.66 (5.27–46.9; 23)

9.29 (5.69–11.6; 20)

9.61 (3.11–15.3; 27)

 IgG serum, QIgG pos

g/l

10.4 (6.2–13.8; 14)

10.7 (6.2–13.8; 13)

n.a. (n.a.; 0)

10.7 (6.2–12.7; 8)

9 (9–9; 1)

11.9 (7.8–13.8; 4)

 Link index, all

Samples

10/75 (13%)

10/67 (15%)

0/6 (0%)

5/22 (22.7%)

1/20 (5%)

4/25 (16%)

 Link index, if positive

Index

0.8 (0.7–0.9; 10)

0.8 (0.7–0.9; 10)

n.a. (n.a.; 0)

0.8 (0.7–0.8; 5)

0.7 (0.7–0.7; 1)

#Value!