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Table 8 CSF findings and attack severity

From: Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 2: Results from 108 lumbar punctures in 80 pediatric patients

 

Units

Severe attacks

Mild/moderate attacks

p value

WCC, all

Cells/μl

28.5 (0–256; 64)

3 (0–179; 26)

0.0000002

WCC, elevated

Samples

47/64 (73.4%)

6/26 (23.1%)

0.00001

WCC, if elevated

Cells/μl

48 (9–256; 47)

12 (6–179;6)

0.016

Neutrophils, all LPs

Samples

16/31 (51.6%)

4/12 (33.3%)

n.s.

OCB, pattern 2 or 3

Samples

10/58 (17.2%)

1/27 (3.7%)

n.s.

Link index

Samples

9/45 (20%)

1/22 (4.5%)

n.s.

QIgG, all

Ratio

2.7 (0.8–8.1; 47)

1.7 (0.8–8.2;23)

0.004

QIgG, elevated

Samples

11/46 (23.9%)

2/23 (8.7%)

n.s.

QIgG, if elevated

Ratio

2.4 (1.5–7; 11)

2.1 (1.7–2.5; 2)

n.s.

QAlb, all

Ratio

5.2 (1.8–15; 48)

3.3 (1.9–11.6; 23)

0.004

Qalb, elevated

Samples

29/48 (60.4%)

7/23 (30.4%)

0.023

QAlb, if elevated

Ratio

7 (4.5–15; 29)

5.3 (4.6–11.6; 7)

n.s.

CSF TP, all

mg/dl

36.5 (14–97.2; 63)

26.1 (13.4–64; 25)

0.008

CSF TP, elevated

Samples

19/61 (31.1%)

2/25 (8%)

0.027

CSF TP, if elevated

mg/dl

60 (46.3–97.2; 19)

59 (54–64; 2)

n.s.

CSF TP, >100 mg/dl

Samples

0/70 (0%)

0/26 (0%)

n.s.

CSF l-lactate, all

mmol/l

1.7 (0.9–2.8; 44)

1.5 (1–2.6; 22)

n.s.

CSF l-lactate, elevated

Samples

16/44 (36.4%)

4/22 (18.2%)

n.s.

CSF l-lactate, if elevated

mmol/l

2 (1.8–2.8; 16)

2.3 (1.9–2.6; 4)

n.s.

CSF l-lactate, >3 mmol/l

Samples

0/48 (0%)

0/22 (0%)

n.s.

  1. Ratios and concentrations are given as median (with range and sample numbers in brackets)
  2. IgG-IF intrathecal IgG fraction, OCB oligoclonal bands, QAlb CSF/serum albumin quotient, TP total protein, WCC white cell count